Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 9/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25840924 | 1.00 | MET (0.39) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL25842800 | 1.00 | MET (0.39) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL30068616 | 1.00 | MET (0.39) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL25844391 | 0.87 | MAP3K12 (0.39) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL25302977 | 0.86 | MAP3K12 (0.38) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL30491391 | 0.86 | MAP3K12 (0.38) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL30068603 | 0.86 | MAP3K12 (0.38) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL25306277 | 0.86 | MAP3K12 (0.38) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL30068812 | 0.86 | MAP3K12 (0.38) | METMAP4K1PIK3CGABL1MAP3K12 | |
| SCHEMBL25299934 | 0.86 | MAP3K12 (0.38) | METMAP4K1PIK3CGABL1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022184152-A1 | FUSED RING SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2022-09-09 | — | — | WO | disclosed |