Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.79 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 3/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8604353 | 1.00 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8111665 | 1.00 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8758555 | 1.00 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9407372 | 0.97 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8107350 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1735796 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10934305 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL29288358 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL597226 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL156916 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108051512-A | The detection method of fluo quinolone drug residual amount in a kind of cow's milk | 佛山科学技术学院 | 2018-05-18 | — | — | CN | claimed |
| CN-104330497-A | Method for determining fluoroquinolone drug residual in beef | LANZHOU INST ANIMAL SCIENCE & VETERINARY PHARMACEUTICS CAAS | 2015-02-04 | — | — | CN | claimed |
| US-20230056260-A1 | ORGANIC AMMONIUM COMPOSITIONS AND METHODS OF THEIR USE AND MAKING | California Safe Soil, LLC | 2023-02-23 | — | — | US | disclosed |
| CN-115595154-A | Selective etching solution for SiGe and Si | 湖北兴福电子材料股份有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| US-20210309582-A1 | ORGANIC AMMONIUM COMPOSITIONS AND METHODS OF THEIR USE AND MAKING | California Safe Soil, LLC | 2021-10-07 | — | — | US | disclosed |
| WO-2021203040-A1 | ORGANIC AMMONIUM COMPOSITIONS AND METHODS OF THEIR USE AND MAKING | California Safe Soil, LLC (US) | 2021-10-07 | — | — | WO | disclosed |
| US-10925995-B2 | Absorber and absorbent article using the same | LIVEDO CORPORATION (JP) | 2021-02-23 | — | — | US | disclosed |
| CN-108051512-A | The detection method of fluo quinolone drug residual amount in a kind of cow's milk | 佛山科学技术学院 | 2018-05-18 | — | — | CN | disclosed |
| CN-104330497-A | Method for determining fluoroquinolone drug residual in beef | LANZHOU INST ANIMAL SCIENCE & VETERINARY PHARMACEUTICS CAAS | 2015-02-04 | — | — | CN | disclosed |
| US-20150024192-A1 | ABSORBER AND ABSORBENT ARTICLE USING THE SAME | LIVEDO CORPORATION (JP) | 2015-01-22 | — | — | US | disclosed |
| US-20110296541-A1 | PRODUCTION OF PROTEINS IN EGGS | UNIVERSITY OF GUELPH (CA) | 2011-12-01 | — | — | US | disclosed |
| US-20090083872-A1 | Production of Proteins in Eggs | UNIVERSITY OF GUELPH (CA) | 2009-03-26 | — | — | US | disclosed |
| EP-1007697-B1 | PRODUCTION OF PROTEINS IN EGGS | UNIV GUELPH (CA) | 2007-03-14 | — | — | EP | disclosed |
| US-20050114916-A1 | Production of proteins in eggs | ETCHES ROBERT J (US) | 2005-05-26 | — | — | US | disclosed |
| US-6861572-B1 | Production of proteins in eggs | ORIGEN THERAPEUTICS, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| EP-1007697-A2 | PRODUCTION OF PROTEINS IN EGGS | UNIVERSITY OF GUELPH (CA) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010505-A2 | PRODUCTION OF PROTEINS IN EGGS | UNIVERSITY OF GUELPH (CA) | 1999-03-04 | — | — | WO | disclosed |
| EP-0544862-B1 | Methods and compositions for the prevention, diagnosis, and treatment of inflammatory serosal diseases and related conditions | BAXTER INT (US) | 1998-03-18 | — | — | EP | disclosed |
| EP-0544862-A1 | Methods and compositions for the prevention, diagnosis, and treatment of inflammatory serosal diseases and related conditions | BAXTER INTERNATIONAL INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992021981-A1 | METHODS AND COMPOSITIONS FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF INFLAMMATORY SEROSAL DISEASE AND RELATED CONDITIONS | BAXTER INTERNATIONAL INC. (US) | 1992-12-10 | — | — | WO | disclosed |