Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189681 | 0.86 | MAPT (0.61) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL189476 | 0.77 | MAPT (0.84) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL190020 | 0.76 | MAPT (0.71) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| Tert-Butyl Formate SCHEMBL27778878 | 0.75 | MAPT (0.57) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL190236 | 0.74 | KDM4E (0.71) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL188615 | 0.74 | MAPT (0.64) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL189705 | 0.71 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL189642 | 0.70 | ALDH1A1 (0.83) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL188898 | 0.70 | MAPT (0.72) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL190297 | 0.69 | MAPT (0.57) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-B9 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-09-26 | — | — | EP | claimed |
| EP-2056829-B1 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-01-04 | — | — | EP | claimed |