Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759902 | 0.88 | PAOX (0.61) | PAOXALDH1A1GAAKDM4EKMT2A | |
| Bicarbonate SCHEMBL30077224 | 0.86 | PAOX (0.50) | PAOXALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL11465052 | 0.84 | PAOX (0.58) | PAOXALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL7994712 | 0.83 | PAOX (0.57) | PAOXALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL14943786 | 0.83 | PAOX (0.62) | PAOXALDH1A1GAAKMT2ACHRM2 | |
| SCHEMBL11813655 | 0.82 | PAOX (0.62) | PAOXALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL9542393 | 0.81 | PAOX (0.55) | PAOXALDH1A1GAAKMT2ACHRM2 | |
| SCHEMBL759447 | 0.80 | PAOX (0.59) | PAOXALDH1A1KMT2AALOX15CHRM2 | |
| SCHEMBL6656746 | 0.80 | PAOX (0.59) | PAOXALDH1A1KMT2AALOX15CHRM2 | |
| SCHEMBL20826637 | 0.80 | PAOX (0.59) | PAOXALDH1A1GAAKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022239734-A1 | POLYOL-BASED MIXED LIQUID COMPOSITION FOR PRODUCING HYDROCHLOROFUROOLEFIN FOAMED POLYURETHANE FOAM, AND USE THEREOF | 東ソー株式会社 | 2022-11-17 | — | — | WO | disclosed |