Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20337653 | 0.86 | TSHR (0.42) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1752108 | 0.82 | KDM4E (0.40) | TSHRALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL29906642 | 0.80 | TSHR (0.48) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1669584 | 0.80 | TSHR (0.48) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7844021 | 0.79 | TSHR (0.47) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31351961 | 0.79 | TSHR (0.47) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2327456 | 0.79 | TSHR (0.47) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23143261 | 0.78 | TSHR (0.46) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2217314 | 0.78 | ALDH1A1 (0.49) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8682515 | 0.78 | HSP90AA1 (0.49) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |