Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30079304 | 0.84 | C5AR1 (0.41) | LMNAALDH1A1DDB1CRBNCCR9 | |
| SCHEMBL30079417 | 0.79 | C5AR1 (0.42) | LMNAALDH1A1NFE2L2MAPT | |
| SCHEMBL30079474 | 0.78 | HRH3 (0.42) | SUV39H2KMT2A | |
| SCHEMBL30079314 | 0.75 | ALDH1A1 (0.41) | LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL31266352 | 0.73 | SLC2A1 (0.46) | LMNANPC1MAPT | |
| SCHEMBL17893575 | 0.71 | ALDH1A1 (0.44) | SUV39H2ALDH1A1LRRK2KMT2AMAPT | |
| SCHEMBL17645550 | 0.68 | HRH4 (0.42) | KMT2AHRH4NPC1RAB9ACCR4 | |
| SCHEMBL19708748 | 0.67 | TP53 (0.37) | SUV39H2LMNAALDH1A1KMT2ATP53 | |
| SCHEMBL7492849 | 0.67 | SUV39H2 (0.40) | SUV39H2LMNAALDH1A1HRH4 | |
| SCHEMBL7489464 | 0.66 | MAPT (0.44) | ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |