Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12068465 | 0.85 | CKS1B (0.48) | CKS1BSKP1SKP2DRD2ALDH1A1 | |
| SCHEMBL4443676 | 0.84 | DRD2 (0.47) | CKS1BSKP1SKP2DRD2KCNA3 | |
| SCHEMBL38659368 | 0.84 | MAPT (0.50) | ALDH1A1LMNAMAPTTDP1KMT2A | |
| SCHEMBL27148465 | 0.84 | CKS1B (0.49) | CKS1BSKP1SKP2DRD2KCNA3 | |
| SCHEMBL3955951 | 0.84 | CKS1B (0.52) | CKS1BSKP1SKP2DRD2ALDH1A1 | |
| SCHEMBL30079446 | 0.83 | DRD2 (0.54) | CKS1BSKP1SKP2DRD2ALDH1A1 | |
| SCHEMBL30079399 | 0.83 | CKS1B (0.48) | CKS1BSKP1SKP2DRD2KCNA3 | |
| SCHEMBL30079575 | 0.83 | CKS1B (0.48) | CKS1BSKP1SKP2DRD2KCNA3 | |
| SCHEMBL30079043 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2DRD2KCNA3 | |
| SCHEMBL30079499 | 0.81 | CKS1B (0.47) | CKS1BSKP1SKP2DRD2KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |