Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.57 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927057 | 1.00 | PIK3CA (0.57) | PIK3CAGRM4CA12CA1CA2 | |
| SCHEMBL30193958 | 0.83 | CA12 (0.53) | PIK3CAGRM4CA12CA1CA2 | |
| SCHEMBL25025671 | 0.83 | CA12 (0.53) | PIK3CAGRM4CA12CA1CA2 | |
| SCHEMBL11394107 | 0.81 | CA12 (0.62) | CA12CA1CA2CA9PDE10A | |
| Hydrochloric Acid SCHEMBL11557292 | 0.80 | CA12 (0.60) | CA12CA1CA2CA9PDE10A | |
| SCHEMBL7695744 | 0.79 | CA12 (0.68) | CA12CA1CA2CA9PDE10A | |
| SCHEMBL11398989 | 0.78 | CA12 (0.62) | GRM4CA12CA1CA2CA9 | |
| SCHEMBL6798468 | 0.78 | CA12 (0.54) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL6354575 | 0.77 | PIK3CA (0.61) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL29581053 | 0.77 | CA12 (0.50) | PIK3CAGRM4CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139306-A1 | KV3 ENHANCERS FOR THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| CN-115380032-A | KV3 enhancers for the treatment of cognitive disorders | 豪夫迈·罗氏有限公司 | 2022-11-22 | — | — | CN | disclosed |