Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.61 |
| ▸ | MTOR | P42345 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35262 | 0.80 | RAB9A (0.61) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL29384795 | 0.80 | RAB9A (0.61) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL10094233 | 0.80 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1373989 | 0.79 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1375752 | 0.79 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL4938262 | 0.79 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1372451 | 0.78 | MEN1 (0.56) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL2284031 | 0.78 | KMT2A (0.50) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL23927057 | 0.77 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL30079596 | 0.77 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6841549-B1 | Condensed imidazole compounds and a therapeutic agent for diabetes mellitus | EISAI CO., LTD. (JP) | 2005-01-11 | — | — | US | disclosed |
| EP-1221444-A1 | FUSED IMIDAZOLE COMPOUNDS AND REMEDIES FOR DIABETES MELLITUS | Eisai Co., Ltd. (JP) | 2002-07-10 | — | — | EP | disclosed |