Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NRAS | P01111 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30085778 | 1.00 | NRAS (0.45) | NRASFLT3IRAK1IRAK4LCK | |
| SCHEMBL28894657 | 1.00 | NRAS (0.45) | NRASFLT3IRAK1IRAK4LCK | |
| SCHEMBL28894932 | 1.00 | NRAS (0.45) | NRASFLT3IRAK1IRAK4LCK | |
| SCHEMBL30085424 | 0.94 | PRKCZ (0.46) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL28894799 | 0.94 | PRKCZ (0.46) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL30085764 | 0.94 | PRKCZ (0.46) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL28895094 | 0.94 | PRKCZ (0.46) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL28894682 | 0.94 | IKBKB (0.51) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL30085791 | 0.94 | IKBKB (0.51) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL30085846 | 0.86 | GBA1 (0.51) | IRAK1IRAK4CHEK1CLK4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115397818-A | Aminopyrimidine derivatives and their use as modulators of arene receptors | 东亚ST株式会社 | 2022-11-25 | — | — | CN | claimed |
| CN-115397818-A | Aminopyrimidine derivatives and their use as modulators of arene receptors | 东亚ST株式会社 | 2022-11-25 | — | — | CN | disclosed |