Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 6/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.58 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.58 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754825 | 1.00 | ULK1 (0.59) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL30086370 | 0.92 | MAPK8 (0.61) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL23764855 | 0.92 | MAPK8 (0.61) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL23764852 | 0.91 | PTK2 (0.66) | ULK1MAPK8PTK2PKMYT1IGF1R | |
| SCHEMBL17544689 | 0.88 | PTK2 (0.72) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL30086170 | 0.88 | PTK2 (0.72) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL23754834 | 0.87 | ULK1 (0.63) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL30086213 | 0.87 | ULK1 (0.63) | ULK1MAPK8PRKAA2PRKAA1ULK2 | |
| SCHEMBL17547457 | 0.85 | ULK1 (0.64) | ULK1MAPK8PRKAA1PTK2FGFR1 | |
| SCHEMBL19654194 | 0.85 | ULK1 (0.65) | ULK1MAPK8PRKAA2PRKAA1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515589-A | ULK1/2 inhibitors and methods of use thereof | 萨克生物研究学院 | 2022-12-23 | — | — | CN | disclosed |
| EP-4103182-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Salk Institute for Biological Studies (US) | 2022-12-21 | — | — | EP | disclosed |