Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25261778 | 1.00 | TERT (0.47) | TERTDOT1LGRM5EPHB4AURKA | |
| SCHEMBL23906566 | 0.89 | TERT (0.49) | TERTDOT1LEGFRSYKTGFBR1 | |
| SCHEMBL30086556 | 0.89 | TERT (0.49) | TERTDOT1LEGFRSYKTGFBR1 | |
| SCHEMBL30086538 | 0.87 | TERT (0.49) | TERTDOT1LEGFRSYKTGFBR1 | |
| SCHEMBL25260684 | 0.87 | TERT (0.49) | TERTDOT1LEGFRSYKTGFBR1 | |
| SCHEMBL25268713 | 0.85 | EPHB4 (0.42) | GRM5EPHB4AURKAEGFRSYK | |
| SCHEMBL30086546 | 0.85 | EPHB4 (0.42) | GRM5EPHB4AURKAEGFRSYK | |
| SCHEMBL23887610 | 0.85 | ABL1 (0.51) | TERTDOT1LAURKAEGFRSYK | |
| SCHEMBL30086592 | 0.85 | ABL1 (0.51) | TERTDOT1LAURKAEGFRSYK | |
| SCHEMBL25225055 | 0.85 | AURKA (0.46) | TERTDOT1LAURKAEGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-11673879-B2 | Substituted pyrimidines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| US-20220372015-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220372015-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | ALK, TYMP, ENTPD5 | TERT 2562/4885DOT1L 2853/4885GRM5 552/4885 |
| US-11673879-B2 | Substituted pyrimidines and methods of use | ALK, TYMP, ENTPD5 | TERT 2562/4885DOT1L 2853/4885GRM5 552/4885 |
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | ALK, TYMP, ENTPD5 | TERT 2562/4885DOT1L 2853/4885GRM5 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.