SCHEMBL30089482

SCHEMBL30089482

O=C(CCC(=O)c1ccc2c(c1)CCC2)c1ccc2c(c1)CCC2

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 7/20 0.69
WNT3A P56704 7/20 0.69
ALDH1A1 P00352 3/20 0.66
MAPT P10636 3/20 0.53
TDP1 Q9NUW8 1/20 0.53
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
HTT P42858 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HPGD P15428 1/20 0.50
HTR1A P08908 1/20 0.49
DRD2 P14416 1/20 0.49
DRD4 P21917 1/20 0.49
HTR2A P28223 1/20 0.49
HTR2C P28335 1/20 0.49
HTR7 P34969 1/20 0.49
DRD3 P35462 1/20 0.49
RXRB P28702 2/20 0.46
RXRA P19793 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30089540 0.96 CTNNB1 (0.73) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL6504541 0.93 ALDH1A1 (0.62) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL15988805 0.91 CTNNB1 (0.65) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL5662017 0.89 ALDH1A1 (0.58) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL817710 0.89 CTNNB1 (0.66) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL15988780 0.88 CTNNB1 (0.68) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL7698853 0.88 CTNNB1 (0.64) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL19287120 0.86 CTNNB1 (0.55) CTNNB1WNT3AALDH1A1MAPTTDP1
SCHEMBL15988831 0.86 NPC1 (0.59) CTNNB1WNT3AALDH1A1NPC1RAB9A
SCHEMBL15988811 0.86 CTNNB1 (0.94) CTNNB1WNT3AALDH1A1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115403459-B Preparation method of 1, 4-dicarbonyl compound 广州自远生物科技有限公司 2024-02-27 CN disclosed
CN-115403459-A Preparation method of 1, 4-dicarbonyl compound 广州自远生物科技有限公司 2022-11-29 CN disclosed