SCHEMBL3009014

SCHEMBL3009014

CC(C)(OB(O)O)C(C)(C)Oc1cn[nH]c1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.32
LMNA P02545 1/20 0.31
APEX1 P27695 1/20 0.31
PMP22 Q01453 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Boric Acid SCHEMBL3009015 0.81 KCNH2 (0.33) KCNH2LMNAAPEX1PMP22
SCHEMBL20970325 0.73 KCNH2 (0.42) KCNH2LMNAAPEX1PMP22
SCHEMBL3009013 0.71 KCNH2 (0.34) KCNH2LMNAAPEX1PMP22
SCHEMBL6004752 0.70 KCNH2 (0.31) KCNH2
SCHEMBL29382796 0.67
SCHEMBL303556 0.62 KCNH2 (0.32) KCNH2LMNAAPEX1PMP22
SCHEMBL15286513 0.62 ROCK2 (0.36) KCNH2LMNAAPEX1PMP22
SCHEMBL875675 0.61
SCHEMBL17649303 0.61 KCNH2 (0.38) KCNH2LMNAAPEX1PMP22
SCHEMBL4153038 0.61 KCNH2 (0.38) KCNH2LMNAAPEX1PMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340559-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE HOLDINGS CORP (US) 2025-11-06 US disclosed
US-12247030-B2 Process for preparing compositions comprising an enantiomeric excess of a substituted pyrrolo[2,3-d]pyrimidine INCYTE HOLDINGS CORPORATION (US) 2025-03-11 US disclosed
EP-4501410-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS Incyte Holdings Corporation (US) 2025-02-05 EP disclosed
EP-3272738-B1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE HOLDINGS CORP (US) 2024-11-13 EP disclosed
US-20210253584-A1 Processes for Preparing Jak Inhibitors and Related Intermediate Compounds INCYTE HOLDINGS CORPORATION 2021-08-19 US disclosed
US-10975085-B2 Process for preparing a composition comprising an enantiomeric excess of greater than or equal to 90% of the (R)-enantiomer of a compound of formula III INCYTE HOLDINGS CORPORATION (US) 2021-04-13 US disclosed
US-10364248-B2 Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine INCYTE CORPORATION (US) 2019-07-30 US disclosed
US-20180237442-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION 2018-08-23 US disclosed
US-9908888-B2 Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines INCYTE CORPORATION (US) 2018-03-06 US disclosed
EP-3272738-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS Incyte Holdings Corporation (US) 2018-01-24 EP disclosed
US-9000161-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2015-04-07 US disclosed
US-8993582-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2015-03-31 US disclosed
US-8883806-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2014-11-11 US disclosed
US-20130253191-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2013-09-26 US disclosed
US-20130253193-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2013-09-26 US disclosed
US-20130253190-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2013-09-26 US disclosed
US-8410265-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2013-04-02 US disclosed
EP-2398774-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS Incyte Corporation (US) 2011-12-28 EP disclosed
US-20100190981-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION 2010-07-29 US disclosed
WO-2010083283-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247030-B2 Process for preparing compositions comprising an enantiomeric excess of a substituted pyrrolo[2,3-d]pyrimidine DPYD, TYMS, TYMP KCNH2 2125/4885LMNA 2873/4885APEX1 260/4885
US-10975085-B2 Process for preparing a composition comprising an enantiomeric excess of greater than or equal to 90% of the (R)-enantiomer of a compound of formula III JAK1, JAK3, JAK2 KCNH2 3258/4885LMNA 3993/4885APEX1 2417/4885
US-20130253193-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885
US-20210253584-A1 Processes for Preparing Jak Inhibitors and Related Intermediate Compounds JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885
US-20130253190-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885
US-10364248-B2 Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine JAK1, JAK3, JAK2 KCNH2 1668/4885LMNA 3907/4885APEX1 2111/4885
US-20180237442-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885
US-20100190981-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885
US-20250340559-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885
US-20130253191-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 KCNH2 3142/4885LMNA 4322/4885APEX1 3017/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.