Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946894 | 1.00 | TGFBR1 (0.42) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16946892 | 0.90 | TGFBR1 (0.45) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL29511265 | 0.86 | NTRK1 (0.49) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16935988 | 0.86 | NTRK1 (0.49) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16946699 | 0.79 | KDM4E (0.46) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16946782 | 0.78 | TGFBR1 (0.46) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16935987 | 0.78 | NTRK1 (0.48) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16946746 | 0.78 | NTRK1 (0.48) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL30092502 | 0.78 | NTRK1 (0.48) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16936087 | 0.78 | NTRK1 (0.45) | TGFBR1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4338739-A2 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-3636649-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-3572416-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2022-09-21 | — | — | EP | disclosed |