Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30094664 | 0.89 | HTR2A (0.58) | CHRNA7TRPM8HTR2AHSD11B1EPHX2 | |
| SCHEMBL30094662 | 0.89 | CHRNA7 (0.61) | CHRNA7TRPM8HSD11B1MEN1KMT2A | |
| SCHEMBL23957100 | 0.78 | CHRNA7 (0.71) | CHRNA7TRPM8 | |
| SCHEMBL23957112 | 0.78 | CHRNA7 (0.86) | CHRNA7MEN1KMT2A | |
| SCHEMBL30094601 | 0.77 | HSD11B1 (0.52) | CHRNA7HTR2AHSD11B1KMT2A | |
| SCHEMBL30094739 | 0.77 | HTR2C (0.41) | CHRNA7HTR2AHTR2CHTR2BEPHX2 | |
| SCHEMBL26597748 | 0.77 | HTR2C (0.43) | CHRNA7HTR2CHTR2BEPHX2MEN1 | |
| SCHEMBL30094734 | 0.77 | CHRNA7 (0.61) | CHRNA7HTR2AHSD11B1KMT2A | |
| SCHEMBL26597637 | 0.77 | HTR2C (0.40) | CHRNA7HTR2AHTR2CHTR2BEPHX2 | |
| SCHEMBL30094811 | 0.74 | CHRNA7 (0.59) | CHRNA7HTR2AHSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403579-A | Novel spiro derivative and application thereof | 上海拓界生物医药科技有限公司 | 2022-11-29 | — | — | CN | disclosed |