Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101890 | 1.00 | PPARG (0.50) | PPARGNTRK1MAPTLMNARXRA | |
| SCHEMBL25305589 | 0.91 | RXRA (0.46) | PPARGRXRAALDH1A1HPGDAKR1B1 | |
| SCHEMBL25864947 | 0.81 | RXRA (0.52) | PPARGRXRAALDH1A1HPGDAKR1B1 | |
| SCHEMBL25261774 | 0.81 | RXRA (0.47) | PPARGMAPTRXRAMEN1ALDH1A1 | |
| SCHEMBL30486780 | 0.81 | RXRA (0.47) | PPARGMAPTRXRAMEN1ALDH1A1 | |
| SCHEMBL25308654 | 0.80 | RXRA (0.47) | PPARGMAPTLMNARXRAMEN1 | |
| SCHEMBL30486778 | 0.80 | RXRA (0.47) | PPARGMAPTLMNARXRAMEN1 | |
| SCHEMBL30389824 | 0.79 | RXRA (0.46) | PPARGNTRK1RXRA | |
| SCHEMBL25260669 | 0.79 | RXRA (0.46) | PPARGNTRK1RXRA | |
| SCHEMBL25306046 | 0.78 | RXRA (0.45) | PPARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116472034-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2023-07-21 | — | — | CN | claimed |
| EP-4165009-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | Nucmito Pharmaceuticals Co., Ltd. (CN) | 2023-04-19 | — | — | EP | claimed |
| CN-117916215-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| EP-4337628-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | Nucmito Pharmaceuticals Company Limited (CN) | 2024-03-20 | — | — | EP | disclosed |
| CN-116472034-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2023-07-21 | — | — | CN | disclosed |
| EP-4165009-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | Nucmito Pharmaceuticals Co., Ltd. (CN) | 2023-04-19 | — | — | EP | disclosed |
| WO-2022242582-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS COMPANY LIMITED (CN) | 2022-11-24 | — | — | WO | disclosed |