Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28899168 | 1.00 | MAP3K5 (0.51) | MAP3K5ROCK1MAP2K1PSEN1PSEN2 | |
| SCHEMBL22473892 | 0.86 | MAP3K5 (0.45) | MAP3K5ROCK1 | |
| SCHEMBL28960066 | 0.84 | MAP3K5 (0.36) | MAP3K5ROCK1MAP2K1 | |
| SCHEMBL22473968 | 0.78 | MAP3K5 (0.46) | MAP3K5 | |
| SCHEMBL28899151 | 0.74 | MAP3K5 (0.53) | MAP3K5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30095505 | 0.74 | MAP3K5 (0.53) | MAP3K5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30095482 | 0.73 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL28899147 | 0.73 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL3951034 | 0.70 | ROCK1 (0.46) | ROCK1MAP2K1 | |
| SCHEMBL28657015 | 0.70 | TSHR (0.45) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |