Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | FADS1 | O60427 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14074698 | 0.84 | ADORA2A (0.60) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL2881001 | 0.78 | ADORA2A (0.57) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL29494878 | 0.76 | ADORA2A (0.56) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL3661823 | 0.76 | ADORA2A (0.56) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL14074693 | 0.76 | ADORA2A (0.56) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL24322141 | 0.73 | AXL (0.38) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL424626 | 0.72 | AXL (0.59) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL6642089 | 0.72 | AXL (0.59) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL30095858 | 0.71 | ADORA2A (0.47) | ADORA2AADORA2BAXLMKNK1MKNK2 | |
| SCHEMBL30095715 | 0.70 | CHEK1 (0.52) | HTR2CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346806-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022251188-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2022-12-01 | — | — | WO | disclosed |