Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL152013 | 0.96 | CYP19A1 (0.45) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL38666248 | 0.93 | CYP19A1 (0.43) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| SCHEMBL27654436 | 0.93 | CYP19A1 (0.43) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| SCHEMBL14856279 | 0.90 | PRKCZ (0.46) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Isoquinoline SCHEMBL1404120 | 0.88 | TNF (0.47) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Isoquinoline SCHEMBL8207083 | 0.88 | TNF (0.47) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Isoquinoline SCHEMBL18062508 | 0.88 | TNF (0.47) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Isoquinoline SCHEMBL18062509 | 0.88 | TNF (0.47) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Isoquinoline SCHEMBL29371152 | 0.88 | TNF (0.47) | CYP19A1PRKCZLMNACYP1A2CYP3A4 | |
| Isoquinoline SCHEMBL5486541 | 0.88 | TNF (0.47) | CYP19A1PRKCZLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4096667-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2022-12-07 | — | — | EP | disclosed |