SCHEMBL30097085

SCHEMBL30097085

COC1(OC)C(=O)CCc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.42
ADRA2A P08913 1/20 0.42
HTR2A P28223 2/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
SIGMAR1 Q99720 1/20 0.38
LMNA P02545 1/20 0.38
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 2/20 0.36
CES1 P23141 1/20 0.36
NPC1 O15118 1/20 0.36
MAPK13 O15264 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TP53 P04637 1/20 0.36
CYP2A6 P11509 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29734668 0.80 CHRM2 (0.44) CHRM2ADRA2AHTR2AHTR2CHTR2B
SCHEMBL29858318 0.75 CHRM2 (0.49) CHRM2ADRA2AHTR2AHTR2CHTR2B
SCHEMBL2061748 0.75 CHRM2 (0.49) CHRM2ADRA2AHTR2AHTR2CHTR2B
SCHEMBL30565205 0.74 HTR2A (0.50) HTR2AHTR2CHTR2BSIGMAR1ALDH1A1
SCHEMBL15733055 0.74 HTR2A (0.50) HTR2AHTR2CHTR2BSIGMAR1ALDH1A1
SCHEMBL18595731 0.72 HTR1A (0.42) CHRM2HTR2ALMNAALDH1A1MAPK1
SCHEMBL4231166 0.72 CHRM2 (0.47) CHRM2ADRA2AHTR2AHTR2CHTR2B
SCHEMBL19505755 0.72 MAPK1 (0.40) CHRM2ADRA2AHTR2ASIGMAR1LMNA
SCHEMBL14358172 0.72 CHRM2 (0.47) CHRM2ADRA2AHTR2AHTR2CHTR2B
SCHEMBL7070214 0.71 CHRM2 (0.42) CHRM2ADRA2AHTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4308573-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME Schrödinger, Inc. (US) 2024-01-24 EP disclosed
WO-2022197898-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME SCHRÖDINGER, INC. (US) 2022-09-22 WO disclosed