SCHEMBL30100735

SCHEMBL30100735

CC1(C)Cc2cc(Nc3ccc(Cl)cn3)ccc2NC1=O

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
BCL6 P41182 1/20 0.41
EGFR P00533 1/20 0.39
TNNI3K Q59H18 1/20 0.39
KIF11 P52732 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ADRA2A P08913 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
AHR P35869 1/20 0.36
PTK2 Q05397 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23674846 1.00 BCL6 (0.41) BCL6EGFRTNNI3KKIF11MEN1
SCHEMBL26088757 0.86 BCL6 (0.43) BCL6KIF11MEN1KMT2APTK2
SCHEMBL30100682 0.82 BCL6 (0.38) BCL6KIF11MEN1KMT2APTK2
SCHEMBL23674636 0.82 BCL6 (0.38) BCL6KIF11MEN1KMT2APTK2
SCHEMBL23674757 0.80 EGFR (0.41) BCL6EGFRKIF11MEN1KMT2A
SCHEMBL30100814 0.79 KIF11 (0.35) BCL6KIF11MEN1KMT2APTK2
SCHEMBL26088442 0.79 KIF11 (0.35) BCL6KIF11MEN1KMT2APTK2
SCHEMBL23674941 0.78 RHOA (0.47) EGFRKIF11MEN1KMT2ARAB9A
SCHEMBL17026793 0.77 AHR (0.54) MEN1KMT2AADRA2AADRA2BADRA2C
SCHEMBL30100704 0.77 KIF11 (0.35) BCL6KIF11PTK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4093400-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF The Trustees of Princeton University (US) 2022-11-30 EP disclosed