Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 3/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30101135 | 0.85 | FGFR4 (0.58) | TNK2FGFR4FGFR2FGFR1BTK | |
| SCHEMBL6940435 | 0.83 | TNK2 (0.85) | TNK2FGFR1 | |
| SCHEMBL30101106 | 0.82 | FGFR4 (0.56) | TNK2FGFR4FGFR2FGFR1RAF1 | |
| SCHEMBL24251869 | 0.78 | FGFR4 (0.62) | TNK2FGFR4FGFR2FGFR1BTK | |
| SCHEMBL28911435 | 0.78 | FGFR4 (0.62) | TNK2FGFR4FGFR2FGFR1BTK | |
| SCHEMBL30101123 | 0.78 | EGFR (0.55) | TNK2FGFR4FGFR2FGFR1RAF1 | |
| SCHEMBL21044814 | 0.76 | TNK2 (0.70) | TNK2BTK | |
| SCHEMBL12903810 | 0.76 | TNK2 (0.70) | TNK2BTK | |
| SCHEMBL4365581 | 0.76 | TNK2 (1.00) | TNK2 | |
| SCHEMBL6944442 | 0.74 | RAF1 (0.62) | TNK2FGFR1RAF1SRCBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433190-B | Preparation method and application of irreversible heterocyclic compound FGFR inhibitor | 药雅科技(上海)有限公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-115433190-A | Preparation method and application of irreversible heterocyclic compound FGFR inhibitor | 药雅科技(上海)有限公司 | 2022-12-06 | — | — | CN | disclosed |