Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383947 | 0.94 | HRH3 (0.61) | HRH3SMN1; SMN2KDM4ETSHRCYP2D6 | |
| SCHEMBL21744253 | 0.89 | HRH3 (0.56) | HRH3DRD1DRD4DRD5TIPARP | |
| SCHEMBL30101340 | 0.86 | HRH3 (0.69) | HRH3DRD1DRD4DRD5TIPARP | |
| SCHEMBL30101386 | 0.86 | HRH3 (0.55) | HRH3TIPARPPOLBKDM4E | |
| SCHEMBL30101435 | 0.86 | HRH3 (0.58) | HRH3TIPARPPOLBKDM4ETSHR | |
| SCHEMBL30101529 | 0.79 | TIPARP (0.55) | HRH3TIPARPKDM4E | |
| SCHEMBL24913864 | 0.75 | CYP2A13 (0.53) | HRH3KDM4ECYP2D6 | |
| SCHEMBL14641573 | 0.74 | KDM4E (0.48) | HRH3SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL14578233 | 0.74 | DRD1 (0.65) | DRD1DRD4DRD5SMN1; SMN2POLB | |
| SCHEMBL30101429 | 0.74 | HRH3 (0.46) | HRH3TIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250034120-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | RIBON THERAPEUTICS, INC. | 2025-01-30 | — | — | US | disclosed |
| US-20230192664-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE | 2023-06-22 | — | — | US | disclosed |
| US-11566020-B1 | Pyridazinones as PARP7 inhibitors | RIBON THERAPEUTICS, INC. (US) | 2023-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250034120-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | PARP2, PARP1, PARP4 | HRH3 1405/4885DRD1 4165/4885DRD4 3518/4885 |
| US-11566020-B1 | Pyridazinones as PARP7 inhibitors | PARP2, PARP1, PARP4 | HRH3 1405/4885DRD1 4165/4885DRD4 3518/4885 |
| US-20230192664-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | PARP2, PARP1, PARP4 | HRH3 1405/4885DRD1 4165/4885DRD4 3518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.