Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30101411 | 0.81 | HRH3 (0.56) | ROCK1ROCK2PRKCDTIPARPPRKCZ | |
| Hydrochloric Acid SCHEMBL31210180 | 0.80 | HRH3 (0.44) | ROCK1ROCK2PRKCDTIPARPPRKCZ | |
| SCHEMBL17585075 | 0.77 | HRH3 (0.56) | KCNH2HRH3 | |
| SCHEMBL3089654 | 0.76 | HRH3 (0.76) | ROCK1HRH3 | |
| SCHEMBL3089656 | 0.76 | HRH3 (0.76) | ROCK1HRH3 | |
| SCHEMBL5201820 | 0.76 | ROCK1 (0.57) | ROCK1ROCK2PRKXPRKCEPRKCD | |
| SCHEMBL3634171 | 0.76 | ROCK1 (0.57) | ROCK1ROCK2PRKXPRKCEPRKCD | |
| SCHEMBL8262308 | 0.75 | HRH3 (0.43) | HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19805885 | 0.75 | ROCK1 (0.54) | ROCK1ROCK2PRKXPRKCEPRKCD | |
| SCHEMBL3158901 | 0.74 | CHRNB2 (0.55) | ROCK1ROCK2PRKXPRKCEPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250034120-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | RIBON THERAPEUTICS, INC. | 2025-01-30 | — | — | US | disclosed |
| US-20230192664-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE | 2023-06-22 | — | — | US | disclosed |
| US-11566020-B1 | Pyridazinones as PARP7 inhibitors | RIBON THERAPEUTICS, INC. (US) | 2023-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250034120-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | PARP2, PARP1, PARP4 | ROCK1 2464/4885ROCK2 1862/4885PRKX 2482/4885 |
| US-11566020-B1 | Pyridazinones as PARP7 inhibitors | PARP2, PARP1, PARP4 | ROCK1 2464/4885ROCK2 1862/4885PRKX 2482/4885 |
| US-20230192664-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | PARP2, PARP1, PARP4 | ROCK1 2464/4885ROCK2 1862/4885PRKX 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.