Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28960772 | 1.00 | HDAC8 (0.57) | HDAC8MAPTBRD4KDM4ESMN1; SMN2 | |
| SCHEMBL18492964 | 0.88 | HDAC8 (0.58) | HDAC8MAPTBRD4KDM4ESMN1; SMN2 | |
| SCHEMBL17144470 | 0.86 | HDAC8 (0.58) | HDAC8MAPTBRD4KDM4ENPC1 | |
| SCHEMBL28960774 | 0.85 | HDAC8 (0.60) | HDAC8MAPTBRD4KDM4ENPC1 | |
| SCHEMBL28965201 | 0.84 | HDAC8 (0.52) | HDAC8MAPTBRD4KDM4ENPC1 | |
| SCHEMBL30102577 | 0.84 | HDAC8 (0.52) | HDAC8MAPTBRD4KDM4ENPC1 | |
| SCHEMBL30102580 | 0.82 | HDAC8 (0.57) | HDAC8MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL17144926 | 0.82 | HDAC8 (0.57) | HDAC8MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL16385293 | 0.82 | MAPT (0.58) | HDAC8MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL17144925 | 0.81 | BRD4 (0.54) | HDAC8MAPTBRD4KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572254-B | 2, 6-Diaryl pyridine HDAC/Tubulin dual-function inhibitor and preparation method and application thereof | 复旦大学 | 2025-04-01 | — | — | CN | disclosed |
| CN-115572254-A | 2, 6-diaryl pyridine HDAC/Tubulin bifunctional inhibitor, preparation method and application | 复旦大学 | 2023-01-06 | — | — | CN | disclosed |