Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.56 |
| ▸ | TUBB | P07437 | 7/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.56 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144926 | 1.00 | HDAC8 (0.57) | HDAC8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18492964 | 0.88 | HDAC8 (0.58) | HDAC8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17144470 | 0.86 | HDAC8 (0.58) | HDAC8PDGFRBKITKDRKDM4E | |
| SCHEMBL17144844 | 0.85 | PDGFRB (0.60) | HDAC8PDGFRBKITKDRALDH1A1 | |
| SCHEMBL30102576 | 0.82 | HDAC8 (0.57) | HDAC8TUBB1PDGFRBKITKDR | |
| SCHEMBL28960772 | 0.82 | HDAC8 (0.57) | HDAC8TUBB1PDGFRBKITKDR | |
| SCHEMBL17144923 | 0.80 | PDGFRB (0.59) | HDAC8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17144996 | 0.79 | KDM4E (0.65) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL28960774 | 0.79 | HDAC8 (0.60) | HDAC8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30102579 | 0.78 | CYP1A1 (0.50) | HDAC8KDM4EMEN1NPC1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572254-A | 2, 6-diaryl pyridine HDAC/Tubulin bifunctional inhibitor, preparation method and application | 复旦大学 | 2023-01-06 | — | — | CN | disclosed |