Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24785078 | 1.00 | CLK4 (0.63) | CLK4DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL20705844 | 0.86 | CLK4 (0.65) | CLK4DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL29786736 | 0.84 | CYP4F2 (0.51) | CLK4DYRK1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28810947 | 0.84 | CYP4F2 (0.51) | CLK4DYRK1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24785094 | 0.84 | CLK4 (0.63) | CLK4DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL17864721 | 0.80 | DYRK1A (0.71) | CLK4DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL30103056 | 0.80 | CLK4 (0.56) | CLK4PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL27807278 | 0.79 | DYRK1A (0.69) | CLK4DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL27785384 | 0.79 | DYRK1A (0.69) | CLK4DYRK1APDGFRBPDGFRACYP1A2 | |
| SCHEMBL4936949 | 0.78 | MAOB (0.54) | CLK4DYRK1ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448913-A | Bicyclic compounds for the treatment of EP2, EP4 receptor mediated diseases | 武汉人福创新药物研发中心有限公司 | 2022-12-09 | — | — | CN | disclosed |