Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077057 | 0.84 | CLK4 (0.58) | CLK4KDM4EMAPTTP53CASP3 | |
| SCHEMBL24784552 | 0.82 | CLK4 (0.56) | CLK4KDM4EMAPTTP53CASP3 | |
| SCHEMBL30103025 | 0.80 | CLK4 (0.63) | CLK4MAPTTP53NPC1RAB9A | |
| SCHEMBL24785078 | 0.80 | CLK4 (0.63) | CLK4MAPTTP53NPC1RAB9A | |
| SCHEMBL507598 | 0.78 | KCNH2 (0.42) | — | |
| SCHEMBL21551139 | 0.77 | NPC1 (0.55) | KDM4EMAPTTP53SIRT2NPC1 | |
| SCHEMBL4416324 | 0.77 | CLK4 (0.64) | CLK4KDM4EMAPTTP53CASP3 | |
| SCHEMBL3236630 | 0.77 | MAOB (0.59) | TP53CASP3SENP8SENP7SENP6 | |
| SCHEMBL13028979 | 0.76 | CLK4 (0.58) | CLK4KDM4EMAPTTP53NPC1 | |
| SCHEMBL9457220 | 0.76 | CASP3 (0.68) | CLK4KDM4EMAPTCASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448913-A | Bicyclic compounds for the treatment of EP2, EP4 receptor mediated diseases | 武汉人福创新药物研发中心有限公司 | 2022-12-09 | — | — | CN | disclosed |