Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801589 | 1.00 | LMNA (0.75) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL30103394 | 0.90 | LMNA (0.65) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL24016846 | 0.88 | LMNA (0.96) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL21163104 | 0.88 | HPGD (0.62) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL4159647 | 0.86 | LMNA (0.61) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL14103288 | 0.86 | LMNA (1.00) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL14454107 | 0.86 | LMNA (0.58) | LMNAHTTKMT2ACYP2C19CYP1A2 | |
| SCHEMBL25278057 | 0.82 | LMNA (0.51) | LMNAHTTKMT2APOLBALDH1A1 | |
| SCHEMBL24016897 | 0.82 | HPGD (0.56) | LMNAHPGDNPC1GLAHTT | |
| SCHEMBL24016862 | 0.82 | LMNA (0.54) | LMNAHPGDNPC1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097138-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | Avila Therapeutics, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |