Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.36 |
| ▸ | FEN1 | P39748 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23205941 | 1.00 | BRD4 (0.39) | BRD4MEN1USP2KMT2AATM | |
| SCHEMBL13241223 | 0.81 | BRD4 (0.48) | BRD4ALOX5APFEN1ALDH1A1KDM5B | |
| Hydrochloric Acid SCHEMBL2997477 | 0.80 | BRD4 (0.47) | BRD4ALOX5APFEN1ALDH1A1KDM5B | |
| SCHEMBL23165874 | 0.75 | KDM4E (0.35) | HSD11B1ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL21602066 | 0.72 | KDM4E (0.46) | BRD4HSD11B1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13923526 | 0.71 | ELANE (0.46) | BRD4MEN1USP2KMT2AATM | |
| SCHEMBL23206297 | 0.70 | BRD4 (0.62) | BRD4MAPTPDE3BPDE3AP2RX7 | |
| SCHEMBL30104760 | 0.70 | BRD4 (0.62) | BRD4MAPTPDE3BPDE3AP2RX7 | |
| SCHEMBL21000574 | 0.69 | FEN1 (0.53) | ALOX5APFEN1ALDH1A1 | |
| SCHEMBL5505270 | 0.69 | AURKA (0.47) | BRD4KMT2AATMALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389009-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GFB (ABC), LLC | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389009-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | CDK5, CDK5R1, PKD1 | BRD4 482/4885MEN1 2841/4885USP2 2245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.