SCHEMBL30104873

SCHEMBL30104873

O=C(Nc1cc(Cl)nc(Cl)c1)Nc1ccccc1CCO

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 3/20 0.60
S1PR2 O95136 2/20 0.57
MEN1 O00255 6/20 0.49
KMT2A Q03164 6/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 1/20 0.49
POLB P06746 3/20 0.46
IGF1R P08069 1/20 0.45
MAPT P10636 4/20 0.44
HTT P42858 2/20 0.44
DHODH Q02127 1/20 0.44
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
CASP3 P42574 2/20 0.43
SENP7 Q9BQF6 2/20 0.43
LMNA P02545 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23831645 1.00 TRPV1 (0.60) TRPV1S1PR2MEN1KMT2ASMN1; SMN2
SCHEMBL30104879 0.89 S1PR2 (0.60) TRPV1S1PR2MEN1KMT2ASMN1; SMN2
SCHEMBL23831653 0.89 S1PR2 (0.60) TRPV1S1PR2MEN1KMT2ASMN1; SMN2
SCHEMBL23831565 0.86 TRPV1 (0.62) TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL23831594 0.86 TRPV1 (0.60) TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL23831696 0.85 S1PR2 (0.55) TRPV1S1PR2MEN1KMT2AIGF1R
SCHEMBL23831802 0.84 TRPV1 (0.57) TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL23831578 0.83 S1PR2 (0.53) TRPV1S1PR2MEN1KMT2ASMN1; SMN2
SCHEMBL23831660 0.82 TRPV1 (0.55) TRPV1S1PR2MEN1KMT2ASMN1; SMN2
SCHEMBL23831812 0.81 TRPV1 (0.63) TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121415-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2023-01-25 EP claimed
EP-4121415-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2023-01-25 EP disclosed