Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.59 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519271 | 1.00 | MAP4K1 (0.59) | MAP4K1SCN10ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30107537 | 0.87 | MAP4K1 (0.63) | MAP4K1 | |
| SCHEMBL20519023 | 0.87 | MAP4K1 (0.63) | MAP4K1 | |
| SCHEMBL20519989 | 0.86 | MAP4K1 (0.47) | MAP4K1NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL30107505 | 0.86 | MAP4K1 (0.47) | MAP4K1NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL30107354 | 0.85 | L3MBTL1 (0.47) | MAP4K1 | |
| SCHEMBL20519528 | 0.85 | L3MBTL1 (0.47) | MAP4K1 | |
| SCHEMBL20519457 | 0.83 | MAP4K1 (0.60) | MAP4K1ABL1 | |
| SCHEMBL30107242 | 0.83 | MAP4K1 (0.60) | MAP4K1ABL1 | |
| SCHEMBL20519263 | 0.81 | MAP4K1 (0.60) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |