Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155216 | 1.00 | NOTUM (0.45) | NOTUMSOS1PDGFRBFGFR1PDGFRA | |
| SCHEMBL31385726 | 0.92 | NOTUM (0.45) | NOTUMSOS1PDGFRBFGFR1PDGFRA | |
| SCHEMBL18420521 | 0.92 | NOTUM (0.45) | NOTUMSOS1PDGFRBFGFR1PDGFRA | |
| SCHEMBL5154161 | 0.90 | SOS1 (0.45) | NOTUMSOS1MAPTALDH1A1KDM4E | |
| SCHEMBL2538919 | 0.88 | KMT2A (0.44) | NOTUMSOS1MAPTALDH1A1KDM4E | |
| SCHEMBL20036871 | 0.88 | KMT2A (0.44) | NOTUMSOS1PDGFRBFGFR1PDGFRA | |
| SCHEMBL3187202 | 0.85 | KDM4E (0.48) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL168324 | 0.85 | CA1 (0.50) | NOTUMSOS1MAPTALDH1A1KDM4E | |
| SCHEMBL21438937 | 0.85 | CCR6 (0.47) | NOTUMSOS1PDGFRBFGFR1PDGFRA | |
| SCHEMBL3411975 | 0.83 | SOS1 (0.48) | NOTUMSOS1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |