Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20518925 | 1.00 | MAP4K1 (0.52) | MAP4K1S1PR2ABL1 | |
| SCHEMBL30107216 | 0.88 | MAP4K1 (0.63) | MAP4K1 | |
| SCHEMBL20518985 | 0.88 | MAP4K1 (0.63) | MAP4K1 | |
| SCHEMBL20519921 | 0.79 | L3MBTL1 (0.50) | MAP4K1ABL1 | |
| SCHEMBL30107289 | 0.79 | L3MBTL1 (0.50) | MAP4K1ABL1 | |
| SCHEMBL20518939 | 0.79 | MAP4K1 (0.40) | MAP4K1ABL1 | |
| SCHEMBL20520009 | 0.79 | GSK3B (0.47) | MAP4K1ABL1 | |
| SCHEMBL30107158 | 0.78 | MAP4K1 (0.52) | MAP4K1S1PR2 | |
| SCHEMBL20519542 | 0.78 | MAP4K1 (0.52) | MAP4K1S1PR2 | |
| SCHEMBL20519440 | 0.78 | MAP4K1 (0.48) | MAP4K1S1PR2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |