Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | EBP | Q15125 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11303598 | 0.81 | CYP2D6 (0.80) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL11303594 | 0.81 | CYP2D6 (0.80) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL11303599 | 0.81 | CYP2D6 (0.80) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL6711976 | 0.80 | NAMPT (0.53) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL6711978 | 0.80 | NAMPT (0.53) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL20208926 | 0.76 | CYP1A2 (0.77) | KCNH2CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL19249594 | 0.75 | KCNH2 (0.46) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL11470018 | 0.73 | SLC6A2 (0.46) | KCNH2CYP1A2CYP2D6CYP2C19NR1I2 | |
| SCHEMBL10474863 | 0.71 | KCNH2 (0.56) | KCNH2CYP1A2LMNAHTTSMN1; SMN2 | |
| SCHEMBL23374065 | 0.69 | KDR (1.00) | LMNAKMT2AKDRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188070-B2 | Method of treating neurological diseases and disorders | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100197661-A1 | Method of Treating Neurological Diseases and Disorders | DREYFUSS GIDEON | 2010-08-05 | — | — | US | disclosed |
| US-20060135509-A1 | Method of treating neurological diseases and disorders | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197661-A1 | Method of Treating Neurological Diseases and Disorders | SMN1; SMN2, CLN6, PMP22 | KCNH2 2577/4885CYP1A2 4361/4885CYP2D6 4396/4885 |
| US-20060135509-A1 | Method of treating neurological diseases and disorders | SMN1; SMN2, CLN6, PMP22 | KCNH2 2577/4885CYP1A2 4361/4885CYP2D6 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.