Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | EBP | Q15125 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6711978 | 1.00 | NAMPT (0.53) | NAMPTBCHEACHENR1I2DRD2 | |
| SCHEMBL9779266 | 0.89 | NR1I2 (0.60) | NAMPTBCHEACHENR1I2DRD2 | |
| SCHEMBL3010793 | 0.80 | KCNH2 (0.52) | NR1I2DRD2ADRA2CCNR1SLC6A2 | |
| SCHEMBL5754749 | 0.78 | LSS (0.55) | NAMPTBCHEACHENR1I2DRD2 | |
| SCHEMBL5754753 | 0.78 | LSS (0.55) | NAMPTBCHEACHENR1I2DRD2 | |
| SCHEMBL11303599 | 0.77 | CYP2D6 (0.80) | NR1I2DRD2ADRA2CCNR1SLC6A2 | |
| SCHEMBL11303594 | 0.77 | CYP2D6 (0.80) | NR1I2DRD2ADRA2CCNR1SLC6A2 | |
| SCHEMBL11303598 | 0.77 | CYP2D6 (0.80) | NR1I2DRD2ADRA2CCNR1SLC6A2 | |
| SCHEMBL19249307 | 0.77 | KCNH2 (0.70) | KCNH2 | |
| SCHEMBL17350043 | 0.76 | KCNH2 (0.72) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170246241-A1 | Methods for the Selective Treatment of Tumors by Calcium-Mediated Induction of Apoptosis | ZEILIG CHARLES E (US) | 2017-08-31 | — | — | US | disclosed |
| US-20140065246-A1 | INTRACELLULAR CALCIUM MODULATION FOR CANCER TREATMENT | ZEILIG CHARLES E (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2004036181-A2 | METHOD OF TREATING NEUROLOGICAL DISEASES AND DISORDERS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-04-29 | — | — | WO | disclosed |