SCHEMBL30107970

SCHEMBL30107970

CN1CCCC(Oc2ccc3c(c2)nnn3-c2ccnc(N)n2)C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AXL P30530 2/20 0.41
KDR P35968 2/20 0.39
INSR P06213 1/20 0.39
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
ROCK1 Q13464 3/20 0.37
HRH3 Q9Y5N1 2/20 0.37
ROCK2 O75116 1/20 0.37
KCNH2 Q12809 1/20 0.37
HRH4 Q9H3N8 1/20 0.37
TTBK1 Q5TCY1 1/20 0.37
PIM1 P11309 1/20 0.36
PIM2 Q9P1W9 1/20 0.36
CCNE1 P24864 2/20 0.36
CDK2 P24941 2/20 0.36
MAPK8 P45983 2/20 0.36
MAPK9 P45984 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30108068 0.82 AXL (0.35) AXLKDRINSRCHRM2CHRM4
SCHEMBL29936727 0.69 CHEK2 (0.43) AXLKDRCHRM2CHRM4CHRM5
SCHEMBL30108046 0.69 KDM4E (0.39) CDK2
SCHEMBL20281698 0.69 PARP1 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL3538827 0.68 PARP1 (0.47) AXLKDRINSRCHRM2CHRM4
SCHEMBL3535759 0.68 HRH3 (0.46) AXLKDRINSRCHRM2CHRM4
SCHEMBL14484041 0.68 HRH3 (0.46) AXLKDRINSRCHRM2CHRM4
SCHEMBL21186296 0.67 CYP3A4 (0.51) AXLKDRINSRCHRM2CHRM4
SCHEMBL13686664 0.66 ROCK1 (0.64) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL13452625 0.66 ALDH1A1 (0.49) KDRCHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022203399-A1 ADENOSINE A2A RECEPTOR ANTAGONIST AND USE THEREOF 주식회사 스탠다임 2022-09-29 WO disclosed