Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.48 |
| ▸ | INSR | P06213 | 4/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30108145 | 0.95 | ALK (0.61) | ALKLRRK2MAPK3INSRIGF1R | |
| SCHEMBL30108134 | 0.88 | ALK (0.52) | ALKINSRIGF1RMAPK8MAPK9 | |
| SCHEMBL30108139 | 0.88 | ALK (0.51) | ALKINSRIGF1RMAPK8MAPK9 | |
| SCHEMBL28728655 | 0.87 | LRRK2 (0.51) | ALKLRRK2MAPK3ZAP70INSR | |
| SCHEMBL30108143 | 0.86 | ALK (0.57) | ALKINSRIGF1RMAPK8MAPK9 | |
| SCHEMBL28728617 | 0.84 | ALK (0.59) | ALKMAPK3ZAP70INSR | |
| SCHEMBL28728854 | 0.84 | LRRK2 (0.47) | ALKLRRK2MAPK3ZAP70INSR | |
| SCHEMBL29594720 | 0.82 | ALK (0.49) | ALKLRRK2MAPK3ZAP70INSR | |
| SCHEMBL25449374 | 0.80 | ZAP70 (0.47) | ALKLRRK2MAPK3ZAP70INSR | |
| SCHEMBL28728761 | 0.80 | ALK (0.60) | ALKMAPK3INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114394974-B | Polysubstituted triaryl macrocyclic compounds and uses thereof | 中国药科大学 | 2022-12-06 | — | — | CN | disclosed |