Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.61 |
| ▸ | INSR | P06213 | 8/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30108147 | 0.95 | ALK (0.55) | ALKINSRLRRK2IGF1RMAPK3 | |
| SCHEMBL30108134 | 0.93 | ALK (0.52) | ALKINSRIGF1R | |
| SCHEMBL30108139 | 0.93 | ALK (0.51) | ALKINSRIGF1R | |
| SCHEMBL30108143 | 0.91 | ALK (0.57) | ALKINSRIGF1R | |
| SCHEMBL28728854 | 0.87 | LRRK2 (0.47) | ALKINSRLRRK2IGF1RMAPK3 | |
| SCHEMBL29594720 | 0.86 | ALK (0.49) | ALKINSRLRRK2IGF1RMAPK3 | |
| SCHEMBL30108135 | 0.85 | ALK (0.53) | ALKINSRLRRK2IGF1R | |
| SCHEMBL30108148 | 0.84 | ALK (0.42) | ALKINSRLRRK2IGF1R | |
| SCHEMBL29595331 | 0.84 | ALK (0.60) | ALKINSRIGF1RMAPK3 | |
| SCHEMBL28728655 | 0.84 | LRRK2 (0.51) | ALKINSRLRRK2IGF1RMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114394974-B | Polysubstituted triaryl macrocyclic compounds and uses thereof | 中国药科大学 | 2022-12-06 | — | — | CN | disclosed |