Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27081712 | 1.00 | MAPT (0.41) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL10839905 | 0.82 | SMN1; SMN2 (0.52) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL26460635 | 0.76 | MAPT (0.43) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL16415760 | 0.76 | MEN1 (0.52) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL5534392 | 0.76 | NPC1 (0.52) | MAPTNPC1SMN1; SMN2RAB9AHTT | |
| SCHEMBL25221217 | 0.74 | SMN1; SMN2 (0.36) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL25619121 | 0.73 | LTA4H (0.43) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL12804678 | 0.71 | CCNB2 (0.49) | MAPTNPC1L3MBTL1MAPK1TDP1 | |
| SCHEMBL21245098 | 0.71 | CA1 (0.47) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL16416752 | 0.70 | LTA4H (0.64) | MAPTNPC1L3MBTL1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313042-A1 | NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Novartis AG (CH) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120053-A | Novel cyclopenta [ c ] pyrrole NR2B negative allosteric modulators | 诺华股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022204337-A1 | NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B | NOVARTIS AG (CH) | 2022-09-29 | — | — | WO | disclosed |