Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 14/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24879360 | 1.00 | PTPN11 (0.36) | PTPN11EGFRLCKJAK3BTK | |
| SCHEMBL24879060 | 0.93 | PTPN11 (0.34) | PTPN11EGFRLCKJAK3BTK | |
| SCHEMBL24879056 | 0.86 | JAK3 (0.41) | PTPN11JAK3BTKPIK3R1PIK3CA | |
| SCHEMBL30111158 | 0.86 | JAK3 (0.41) | PTPN11JAK3BTKPIK3R1PIK3CA | |
| SCHEMBL27216052 | 0.84 | PTPN11 (0.36) | PTPN11EGFRLCKJAK3BTK | |
| SCHEMBL30111125 | 0.84 | PTPN11 (0.36) | PTPN11EGFRLCKJAK3BTK | |
| SCHEMBL23064011 | 0.83 | PTPN11 (0.36) | PTPN11JAK3BTKCKS1BSKP1 | |
| SCHEMBL16925239 | 0.81 | JAK3 (0.39) | PTPN11EGFRLCKJAK3BTK | |
| SCHEMBL29498065 | 0.81 | JAK3 (0.39) | PTPN11EGFRLCKJAK3BTK | |
| SCHEMBL31013106 | 0.81 | L3MBTL1 (0.33) | PTPN11JAK3BTKCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023282702-A1 | SHP2 INHIBITOR AND USE THEREOF | 주식회사 카나프테라퓨틱스 | 2023-01-12 | — | — | WO | disclosed |