Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17150937 | 1.00 | CASR (0.50) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL4824743 | 0.86 | HPGD (0.51) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL9700340 | 0.82 | NISCH (0.47) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL18301039 | 0.82 | HPGD (0.48) | CASRHPGDHTR1ANISCH | |
| SCHEMBL3969660 | 0.82 | CASR (0.47) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL2638179 | 0.82 | CASR (0.47) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL3969657 | 0.82 | CASR (0.47) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL8570483 | 0.82 | CASR (0.47) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL8562491 | 0.81 | CASR (0.47) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL9701396 | 0.81 | CASR (0.56) | CASRHPGDHTR1ANISCHBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367113-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | Biogen MA Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023283610-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |