Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Resatorvid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 known ✓ | O00206 | 9/20 | 1.00 |
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.43 |
| ▸ | TSPO | P30536 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Resatorvid SCHEMBL29607069 | 1.00 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL871572 | 1.00 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL1821271 | 1.00 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL872197 | 1.00 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| SCHEMBL871253 | 0.97 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| SCHEMBL871685 | 0.94 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944442 | 0.90 | TLR4 (0.82) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944682 | 0.90 | TLR4 (0.82) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944518 | 0.90 | TLR4 (0.82) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944446 | 0.90 | TLR4 (0.85) | TLR4MRGPRX1TSPOHRH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110368-A1 | TREATMENT OF LIVER FAILURE | Hepyx Limited (GB) | 2023-01-04 | — | — | EP | disclosed |