Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Resatorvid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 known ✓ | O00206 | 9/20 | 0.85 |
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.42 |
| ▸ | TSPO | P30536 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Resatorvid SCHEMBL13944467 | 0.93 | TLR4 (0.79) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944450 | 0.93 | TLR4 (0.79) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| SCHEMBL871685 | 0.92 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944616 | 0.92 | TLR4 (0.75) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL13944527 | 0.92 | TLR4 (0.72) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL30113148 | 0.90 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL29607069 | 0.90 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL1821271 | 0.90 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL871572 | 0.90 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A | |
| Resatorvid SCHEMBL872197 | 0.90 | TLR4 (1.00) | TLR4MRGPRX1TSPOHRH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090022706-A1 | SUBSTITUTED CYCLOHEXENES | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090022706-A1 | SUBSTITUTED CYCLOHEXENES | TLR4, TLR2, TLR1 | TLR4 1/4885MRGPRX1 306/4885TSPO 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.