Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.50 |
| ▸ | YAP1 | P46937 | 1/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.36 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24879883 | 1.00 | TEAD1 (0.50) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879863 | 0.97 | TEAD1 (0.51) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879914 | 0.90 | TEAD1 (0.44) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24880012 | 0.87 | TEAD1 (0.51) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879934 | 0.87 | TEAD1 (0.42) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24880172 | 0.87 | TEAD1 (0.50) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879998 | 0.84 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24880010 | 0.84 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879997 | 0.84 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL30114385 | 0.84 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594680-A | TEAD inhibitor | 武汉人福创新药物研发中心有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |