Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 6/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24879863 | 0.92 | TEAD1 (0.51) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24879934 | 0.91 | TEAD1 (0.42) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL30114160 | 0.90 | TEAD1 (0.50) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24879883 | 0.90 | TEAD1 (0.50) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24879918 | 0.85 | WDR5 (0.35) | TEAD1WDR5NPC1LMNAGAA | |
| SCHEMBL30135282 | 0.81 | TEAD1 (0.66) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24788980 | 0.81 | TEAD1 (0.66) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24880012 | 0.80 | TEAD1 (0.51) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24880172 | 0.80 | TEAD1 (0.50) | TEAD1YAP1BRAFTNNI3KMAPT | |
| SCHEMBL24880000 | 0.78 | TEAD1 (0.47) | TEAD1YAP1TNNI3KMAPTWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023280254-A1 | TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-01-12 | — | — | WO | disclosed |