Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.52 |
| ▸ | KIT | P10721 | 8/20 | 0.52 |
| ▸ | BCR | P11274 | 7/20 | 0.52 |
| ▸ | ABL2 | P42684 | 5/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | FGR | P09769 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | NQO2 | P16083 | 2/20 | 0.52 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.52 |
| ▸ | FRK | P42685 | 2/20 | 0.52 |
| ▸ | BLK | P51451 | 2/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21799050 | 1.00 | ABL1 (0.52) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL30530290 | 0.92 | JAK2 (0.49) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL21799091 | 0.92 | JAK2 (0.49) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL21799066 | 0.91 | ABL1 (0.54) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL30530294 | 0.91 | ABL1 (0.54) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL21799098 | 0.89 | AXL (0.51) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL30530302 | 0.89 | AXL (0.51) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL30114791 | 0.87 | ABL1 (0.51) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL20188202 | 0.87 | ABL1 (0.51) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL21799061 | 0.87 | ABL1 (0.41) | ABL1KITBCRPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | claimed |
| EP-3544685-B1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEV CT BIOTECHNOLOGY (TW) | 2023-01-04 | — | — | EP | claimed |
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | disclosed |
| EP-3544685-B1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEV CT BIOTECHNOLOGY (TW) | 2023-01-04 | — | — | EP | disclosed |