Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 10/20 | 0.51 |
| ▸ | KIT | P10721 | 9/20 | 0.51 |
| ▸ | BCR | P11274 | 4/20 | 0.51 |
| ▸ | ABL2 | P42684 | 6/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DDX3X | O00571 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30530302 | 1.00 | AXL (0.51) | AXLABL1KITBCRABL2 | |
| SCHEMBL20191208 | 0.92 | JAK2 (0.58) | LCKKDRMAPK14JAK2JAK3 | |
| SCHEMBL21799050 | 0.89 | ABL1 (0.52) | AXLABL1KITBCRABL2 | |
| SCHEMBL30114643 | 0.89 | ABL1 (0.52) | AXLABL1KITBCRABL2 | |
| SCHEMBL20188193 | 0.88 | ABL1 (0.52) | AXLABL1KITBCRABL2 | |
| SCHEMBL21799069 | 0.86 | JAK2 (0.47) | ABL1BCRKDRMAPK14DDR1 | |
| SCHEMBL30530282 | 0.86 | JAK2 (0.47) | ABL1BCRKDRMAPK14DDR1 | |
| SCHEMBL30530281 | 0.84 | ABL1 (0.53) | ABL1KITBCRABL2ABCB1 | |
| SCHEMBL20191064 | 0.84 | ABL1 (0.52) | AXLABL1KITBCRABL2 | |
| SCHEMBL20188567 | 0.84 | ABL1 (0.53) | ABL1KITBCRABL2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544685-B1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEV CT BIOTECHNOLOGY (TW) | 2023-01-04 | — | — | EP | claimed |
| US-10793542-B2 | Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-10-06 | — | — | US | claimed |
| US-20200079753-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-03-12 | — | — | US | claimed |
| EP-3544685-B1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEV CT BIOTECHNOLOGY (TW) | 2023-01-04 | — | — | EP | disclosed |
| US-10793542-B2 | Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-10793542-B2 | Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-20200079753-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079753-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | SHH, GLI1, SMO | AXL 3560/4885ABL1 1218/4885KIT 274/4885 |
| US-10793542-B2 | Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof | SHH, GLI1, NR1H4 | AXL 2218/4885ABL1 1395/4885KIT 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.