Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470221 | 1.00 | PTGER4 (0.37) | PTGER4ALDH1A1LMNASMN1; SMN2RHEB | |
| SCHEMBL2356746 | 0.88 | PTGER4 (0.48) | PTGER4TP53KMT2AAGTR2MAPT | |
| SCHEMBL2351917 | 0.88 | HRH3 (0.38) | PTGER4ALDH1A1LMNATP53AGTR2 | |
| SCHEMBL30114876 | 0.88 | HRH3 (0.38) | PTGER4ALDH1A1LMNATP53AGTR2 | |
| SCHEMBL6713139 | 0.87 | PTGER4 (0.40) | PTGER4AGTR2 | |
| SCHEMBL30114744 | 0.87 | PTGER4 (0.37) | PTGER4TP53KMT2AAGTR2MAPT | |
| SCHEMBL21470223 | 0.87 | PTGER4 (0.37) | PTGER4TP53KMT2AAGTR2MAPT | |
| SCHEMBL21470115 | 0.84 | AGTR2 (0.37) | PTGER4TP53KMT2AAGTR2MAPT | |
| SCHEMBL30114922 | 0.84 | AGTR2 (0.37) | PTGER4TP53KMT2AAGTR2MAPT | |
| SCHEMBL1625476 | 0.81 | RHEB (0.38) | ALDH1A1RHEBSIRT2SIRT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976105-B1 | USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE | ASKAT INC (JP) | 2023-01-04 | — | — | EP | disclosed |